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Interstates
| Interstate | TN border, Faust - Asheville (I-240, I-40) - Hendersonville (US-25) - Columbus (US-74), SC border | |
| Interstate | TN border, Waterville - Clyde (US-74) - Asheville (I-26, I-240) - Morganton - Hickory (US-321) - Conover - Statesville (I-77) - Winston-Salem (I-40 BUS/US-421, US-52, US-311) - Kernersville (I-74, I-40 BUS) - Greensboro (I-73, I-85 BUS, I-85/I-840) - Burlington - Hillsborough (I-85) - Chapel Hill - Lowes Grove (NC-147) - Raleigh-Durham Intl Airport (I-540) - Raleigh (I-440/US-1) - Auburn (I-640) - Benson (I-95) - Magnolia - Wilmington (US-17 BYP) | |
| Interstate | VA border, Price - Greensboro (I-785, I-40, I-85) - Sophia (I-74) - Asheboro - Candor - Rockingham (I-74) - SC border (now signed as parts of US-220, US-1) | |
| Interstate | Pine Ridge (I-77) - Mount Airy (US-52) - King (I-274/I-285) - Winston-Salem bypass (I-40 BUS, I-40) - Union Cross (US-311) - High Point (I-85) - Sophia (I-73) - Asheboro - Candor - Rockingham (I-73) - Hamlet - Laurinburg - Lumberton (I-95) - Whiteville - Bolton - Supply - Calabash, SC border (now signed as parts of US-52, US-311, US-74, NC-211, US-17) | |
| Interstate | SC border, Charlotte (I-485, I-277, I-85) - Statesville (I-40) - Brooks Crossroads (US-421) - Elkin (US-21) - Pine Ridge (I-74), VA border | |
| Interstate | SC border, Grover - Kings Mountain (US-74) - Gastonia (US-321) - Charlotte (I-485, NC-16, I-77) - Concord - Kannapolis - Salisbury - Lexington (US-52 future I-285) - High Point (I-74) - Greensboro (I-73, I-85 BUS, I-40/I-840) - Burlington - Hillsborough (I-40) - Durham (NC-147, US-15/US-501, US-70) - Oxford - Henderson (US-1) - Wise, VA border | |
| Interstate | SC border, Rowland - Lumberton (I-74) - Fayetteville (NC-87, I-295) - Dunn - Benson (I-40) - Smithfield (US-70) - Wilson (US-264) - Rocky Mountain (US-64) - Roanoke Rapids, VA border | |
| Interstate | Asheville: I-26/I-40 - I-26 - I-40 | |
| Interstate | Winston-Salem Western Beltway: Clemmons (I-40) - Lewisville (US-421) - King (I-74) | |
| Interstate | Downtown Charlotte Inner Loop: I-40 - US-74 - I-40/NC-16 | |
| Interstate | Lexington (I-85) - Winston-Salem (I-40, I-40 BUS) - King (I-74/I-274) (signed as US-52) | |
| Interstate | Fayetteville Outer Loop: Hope Mills (I-95) - Spring Lake - US-401 - Eastover (I-95) | |
| Cliff Benson Beltline | Raleigh Inner Beltway | |
| Interstate | Charlotte Outer Beltway (partly U/C, planned) | |
| Interstate | Raleigh Outer Beltway: Carpenter - Raleigh-Durham Intl Airport (I-40) - New Hope - Knightdale (US-64) - Auburn (I-40) (planned to be changed to Interstate I-640 once the northeastern half of the beltway is completed) | |
| Interstate | Greensboro (I-840) - Reidsville - Pelham, VA border (signed as US-29) | |
| Interstate | Greensboro Loop: I-40/I-80 - Burlington Rd - I-785 - I-73 |
Business Interstates
| Interstate | Winston-Salem (I-40, US-52) - Kernersville (I-40) | |
| Interstate | Greensboro: I-85/I-73 - US-220 - I-40 |
US Highways
| Freeway | Southern Pines - Sanford - Raleigh (I-40/I-440) // Bearpond - Henderson (I-85) | |
| Freeway | Bethel - US-64 | |
| Freeway | Durham: University Dr - I-85 | |
| Freeway | Easy Hill (US-74) - Wilmington // Jacksonville bypass // New Bern (US-70) - Bridgeton // Williamston bypass (US-64) // Elizabeth City bypass | |
| Freeway | Wilmington bypass (I-40) | |
| Freeway | I-77 - Elkin | |
| Freeway | SC border - Tuxedo - Hendersonville (I-26) | |
| Freeway | High Point (I-74) - I-85 // I-40 - Greensboro // Reidsville - Pelham, VA border (portion Reidsville - VA future Interstate I-785) | |
| Freeway | Charlotte: I-85 - US-29 | |
| Freeway | Mount Airy (I-74) - King (I-74/I274) - Winston-Salem (I-40 BUS, I-40) - Lexington (I-85) (portion Mt. Airy - King future Interstate I-74; portion King - Lexington future Interstate I-285) | |
| Freeway | Pittsboro bypass // Raleigh (I-440) - Knightdale (I-640) - Zebulon (US-264) - Rocky Mount (I-95) - Tarboro - Bethel (US-13) - Williamston (US-17) // Plymouth - Roper - Scuppernong | |
| Freeway | Durham: I-85 - Holloway St // Smithfield (I-95) // Goldsboro bypass (US-117) // Dover - New Bern (US-17) | |
| Freeway | Bryson City - Sylva // Waynesville - Clyde (I-40) // Columbus (I-26) - Forest City (US-74 ALT) - Mooresboro // Shelby - Kings Mountain (I-85) // I-277 - Charlotte // Rockingham (US-220) - Hamlet // Laurinburg - Alma // Chadbourn - Whiteville // Leland - Easy Hill (US-17) (portion Rockingham - Whiteville future I-74) | |
| Freeway | Forest City (US-74) - Rutherfordton | |
| Freeway | Goldsboro (US-70) - Wilson (US-264) | |
| Freeway | Greensboro (I-40, I-85 BUS, I-85) - Sophia (US-311 future I-74) - Asheboro - Candor - Rockingham (US-74) (future Interstates I-73/I-74) | |
| Freeway | Zebulon (US-64) - Wilson (I-95, US-117) - Farmville - Greenville | |
| Freeway | Winston-Salem (I-40) - High Point (US-29, I-85) - Sophia (US-220) (future Interstate I-74) | |
| Freeway | Gastonia (I-85) - Lincolnton - Hickory (I-40) | |
| Freeway | Fayetteville western bypass (NC-87) | |
| Freeway | Wilkesboro - Brooks Crossroads (I-77) - Winston-Salem (I-40/I-40 BUS) // Staley - Siler City | |
| Freeway | Clinton bypass |
State Highways
| Freeway | Charlotte: I-77/I-277 - I-85 | |
| Freeway | Holly Springs bypass | |
| Silas Creek Parkway | Winston-Salem: Stratford Rd - I-40 BUS - Country Club Rd | |
| Freeway | Greensboro: I-40 - Piedmont Triad Intl Airport | |
| Freeway | I-95 - Fayetteville | |
| Durham Freeway | Durham (I-85, US-15/US-501) - Lowes Grove (I-40) |
Unnumbered Highways
| Airport Parkway, Joseph Bryan Boulevard |
Greensboro: NC-68 - Piedmont Triad Intl Airport - Benjamin Pkwy |
| All American Freeway | Fayetteville: Honeycutt Rd - Owen Dr |
| Aviation Parkway | I-540 - Raleigh-Durham Intl Airport |
| Billy Graham Parkway | Charlotte: I-40 - West Blvd |
| Birmingham Parkway | Charlotte - Charlotte-Douglas Intl Airport |
| Wade Avenue | Raleigh: I-40 - I-440 |
| Wendover Avenue | Greensboro: Manley Ave - US-220 - Grecade St |
Standards
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Freeway standard |