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South Carolina
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Interstates
| Interstate | GA border, North Augusta - Lexington - St. Andrews (I-26) - Dentsville (SC-277, I-77) - Camden - Florence (I-95) | |
| Interstate | NC border, Landrum - Spartanburg (I-85, I-85 BUS) - Clinton (I-385) - Newberry - St. Andrews (I-20, I-126) - West Columbia - Starmount (I-77) - Orangeburg - Whetsell (I-95) - Summerville - North Charleston (I-526) - Charleston | |
| Interstate | Briarcliffe Acres (SC-31 future I-174) - Knotty Branch - Marion - Grove (I-95) - Bennettsville, NC border (opened portion signed as SC-22) | |
| Interstate | Starmount (I-26) - Columbia - Dentsville (I-20) - Killian (SC-277) - Rock Hill - Fort Mill, NC border | |
| Interstate | GA border, Fairplay - Anderson - Greenville (I-185, I-385) - Spartanburg (I-85 BUS, I-26, I-85 BUS) - Gaffney - Blacksburg, NC border | |
| Interstate | FL border, Hardeeville - Walterboro - Whetsell (I-26) - Florence (I-20) - Dillon - Hamer, NC border | |
| Interstate | St. Andrews (I-26) - Columbia | |
| Interstate | Briarcliffe Acres (SC-22 future I-73) - North Myrtle Beach (now part of SC-31) | |
| Interstate | Greenville (I-85) - Mauldin (I-385) | |
| Interstate | Clinton (I-26) - Laurens - Mauldin (I-185) - Greenville (I-85) | |
| Bobby Jones Expressway | GA border - North Augusta | |
| Mark Clark Expressway | Johns Island - North Charleston (I-26) - Mount Pleasant | |
| Interstate | I-85 BUS - Spartanburg |
Business Interstates
| Interstate | Spartanburg: I-80 - I-26 - I-585 - I-85 |
US Highways
| Freeway | Clemson - Easley | |
| Cross Island Parkway | Hilton Head Island: Windmill Harbor - Bay Pines | |
| Freeway | Sumter bypass |
State Highways
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Freeway | West Columbia - Columbia |
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Conway Bypass | Knotty Branch - Briarcliffe Acres (SC-31) (future Interstate I-73) |
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North Myrtle Beach Connector | Myrtle Beach - Briarcliffe Acres (SC-22) - North Myrtle Beach (portion SC-22 - Nth Myrtle Beach is future Interstate I-174) |
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Northeastern Freeway | Columbia - Dentsville (I-20) - Killian (I-77) (to be upgraded to I-277) |
Standards
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Freeway standard |